Activation of the extracellular signal regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by ...
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The KIMMKP3 peptide binds ERK2 in an extended conformation covering a contiguous surface area (the docking site) situated on the opposite of the ERK2 active ...
May 26, 2023 · In the NP-ERK2 structure (pdb: 2gph), the docking peptide is involved in extensive electrostatic interactions with the CD-site. All the ...
Nov 10, 2010 · The crystal structure of inactive ERK2 in complex with a DCC peptide reveals a docking motif-mediated binding of DCC to ERK2. We discover that ...
Jul 11, 2019 · We tested the interaction of rERK2 wild type and the CD site mutants D-N and E-K with a D/KIM-containing peptide corresponding to residues 712– ...
Apr 9, 2013 · 20). The ERK2 D-peptide-binding site is targeted by proteins that contain a distinctive D-motif (also termed DEJL/docking site for ERK and ...
Jul 4, 2006 · Here, we report a 1.9 A crystallographic analysis of inactive ERK2 bound to a "D motif" docking peptide (pepHePTP) derived from hematopoietic ...
Structural models of ERK were examined to compare regions that were solvent protected by DEF peptide binding with likely sites of hydrophobic interaction.
peptide binds ERK2 in an extended conformation covering a contiguous surface area (the docking site) situated on the opposite of the ERK2 active site (Fig.
C) Binding of the D-site peptide RLQERRGSNVALMLDV ... derived from hematopoietic protein tyrosine phosphatase, to unactivated ERK2. ... The N-terminal docking site ...